Make the most of a three-day stay in one of Central America’s most stunning cities. Located at the Pacific entrance of the Panama Canal, as a one-stop travel destination, Panama City often flies under the radar. But in-the-know travelers will find world-class restaurants and fascinating history nestled beside lush jungle and sandy beaches.
Historically, the canal meant this city was the spot where commerce from all over the world converged, creating a thrilling confluence of cultures that can still be felt today in the diverse architecture, inventive cuisine, and fantastic shopping.
As always, check for travel guidelines and closures before planning your trip.
Friday: Visit a UNESCO World Heritage Site
For your first day in Panama City, start off with a stroll along the waterfront Cinta Costera Park. Enjoy the miles of pathways, adjacent to Avenida Balboa, the city’s main thoroughfare. Watch joggers, tennis players, and basketball players do their thing and admire the city skyline and the sea.
For breakfast, make a stop at the nearby Restaurant Boulevard Balboa for Cuban-inspired fare. Opt for the eggs with Catalan sausage and grab a seat on the patio, which has ocean views and a refreshing ocean breeze coming through.
From here, take a taxi to the Amador Causeway and visit the Biomuseo. Designed by Frank Gehry, this colorful museum houses ultramodern displays detailing the rich natural history of Panama and showing how the Isthmus of Panama served as a land bridge that altered migration, evolution, and the climate.
Walk to the end of the scenic Amador Causeway for lunch at Beirut, known for traditional Lebanese shared plates and great city views. Once you’re settled up, head back toward the Biomuseo, stopping at the Smithsonian’s Punta Culebra Tropical Research Institute to watch mesmerizing sharks, turtles and fish. A short trail takes you through an area where you might spot sloths and armadillos.
Hop in a taxi to the Panamá Viejo archaeological site, designated a UNESCO World Heritage site in 1997. Maps, artifacts and dioramas cover the city’s history, with a location atop its first European settlement by the Spanish in 1519. An earthquake leveled most of the original settlement, but you can tour a few of the remaining buildings.
For dinner, check out Maito for once in a lifetime fusion cuisine at one of Latin America’s most lauded restaurants. At Maito, expect chic presentations and perfectly crafted flavor combinations — from pork chuletón with papaya glaze to crispy duck chow mein to creamy rice with seafood and plantain chips.
Cap off the night with a distinct craft cocktail like the Venao with gin, sake, Panamanian orgeat, and lime at Amano.
Saturday: Explore Casco Viejo
Casco Viejo — both the oldest and hippest neighborhood in Panama City — deserves a day dedicated to shopping, eating, and sightseeing.
For breakfast (or brunch, depending on your alarm time), make a stop at Café Unido, which has some of the best coffee in town, with all its beans grown in Panama, along with a menu excellent breakfast sandwiches, egg scrambles, and açaí bowls. From here, head to the remains of the Santo Domingo Church and don’t miss the interestingly flat, 50-foot brick arch built by Dominican friars.
Next up: shopping. For modern designer jewelry with recycled elements, pop into Mitchelle Q. Joyería. Browse or buy at the DiabloRosso art gallery, which highlights the work of local artists and has sold pieces to the Guggenheim.
Once hunger hits, you’re off to one of the city’s buzziest spots. The country’s first craft brewpub now has multiple outlets around Panama City, but the original Casco Viejo location of La Rana Dorada continues to shine. Choose from six house craft brews on tap, and pair it all with well-executed bar food, including excellent empanadas, ceviche, and nachos.
In preparation for tomorrow’s Panama Canal adventure, visit the nearby Canal Museum of Panama, where exhibits cover the history of the canal, as well as the engineering.
Your next stop is the Metropolitan Cathedral, which was completed in the late 1700s after a century of construction and features a mix of architectural styles. It anchors Plaza de la Independencia — where modern Panama was born when the nascent country declared its independence from Colombia in 1903.
From here, explore the nation’s indigenous crafts and fine art, with a stunning array of beaded baskets, vases, bags, and masks at La Galeria Indigena.
For dinner, make a reservation at Fonda Lo Que Hay for dinner that celebrates Panama’s culinary traditions and evolution, and its freshest produce. The menu includes a stunning array of seafood dishes, including seafood curry empanadas, as well as fresh salads and beef options from traditional rice and bean dishes to cacao e pepe. For a more casual seafood feast grounded in the freshest local catches served fried or in ceviche, walk in to Grill Sabores del Chorrillo.
For a lovely nightcap after dinner, head to the Strangers Club for artful cocktails with a focus on tequila, mezcal and rum.
Sunday: Take a Ride Through the Panama Canal
You’re hitting the water today, so grab some coffee (and a snack) at your hotel before kicking off your final morning in Panama City. The Panama Canal is central to the city’s economy and industry, so a tour of this historic waterway is a quintessential part of any trip.
You can book a partial or complete tour of the canal with Panama Marine Adventures. Partial transits pass through the Miraflores lock, the San Miguel lock and the Culebra Cut, giving you a unique glimpse of the city that you can’t find at any other vantage point.
Full transits travel from the Pacific Ocean to the Atlantic Ocean through all six locks on the original Panama Canal — plus the Culebra Cut and Gatún Lake. All transits include breakfast and lunch, a guide to explain canal history, engineering and the process of moving vessels (carefully!) through the locks.
The canal tour will take up the majority of your morning and afternoon, so once you hit dry land, it’s already time to start thinking about dinner.
On that note, enjoy what the first winner of “Top Chef Panama,” chef Hernán Correa, serves up at his Riesen Restaurante, where he uses hyperlocal ingredients for menus featuring dishes like Panamanian-style ceviche, Indigenous rice porridge and cold-smoked yellowfin tuna.
To cap off a weekend in Panama City, head to Soléo at the oceanfront Westin Playa Bonita for cocktails and let-your-hair-down fun. Many nights deliver special activities like salsa dancing lessons or karaoke.
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